Publications by the MitoSciences Team



  2011

Nadanaciva S, Murray J, Wilson C, Gebhard DF, Will Y. (2011) "High-throughput assays for assessing mitochondrial dysfunction caused by compounds that impair mtDNA-encoded protein levels in eukaryotic cells." Curr Protoc Toxicol.

Li Q, Velde CV, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland DW, Miller TM. (2010) "ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import." PNAS.

Lyman SK, Crawley SC, Gong R, Adamkewicz JI, McGrath G, Chew JY, Choi J, Holst CR, Goon LH, Detmer SA, Vaclavikova J, Gerritsen ME, Blake RA. (2011) "High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888." PLoS One. 2011 Mar 7;6(3):e17692.

  2010

Li Q, Velde CV, Israelson A, Xie J, Bailey AO, Dong MQ, Chun SJ, Roy T, Winer L, Yates JR, Capaldi RA, Cleveland DW, Miller TM. (2010) "ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import." PNAS. 2010 Oct 18.

Deutsch EC, Santani AB, Perlman SL, Farmer JM, Stolle CA, Marusich MF, Lynch DR. (2010) "A rapid, noninvasive immunoassay for frataxin: Utility in assessment of Friedreich ataxia." Mol Genet Metab. 2010 Jul 8. [Epub ahead of print].

  2009

Marusich MF, Murray J, Xie J, Capaldi RA. (2009) "Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction." Int J Biochem Cell Biol 41: 2081-2088.

Möpert K, Hajek P, Frank S, Chen C, Kaufmann J, Santel A. (2009) "Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization." Exp Cell Res. 315(13):2165-80.

Nadanaciva S, Willis JH, Barker ML, Gharaibeh D, Capaldi RA, Marusich MF, Will Y. (2009) "Lateral-flow immunoassay for detecting drug-induced inhibition of mitochondrial DNA replication and mtDNA-encoded protein synthesis." J Immunol Methods 343:1-12.

Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi R, Dunham LD, Trimmer PA, Bennett JP Jr. (2009) "Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues." Biochim Biophys Acta. 2009 Jan;1792(1):68-74.

Willis JH, Capaldi RA, Huigsloot M, Rodenburg RJ, Smeitink J, Marusich MF. (2009) "Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays." Biochim Biophys Acta 1787(5):533-8.

  2008

Murray J, Capaldi RA. (2008) "Screening for the metabolic basis of neurodegeneration: developing a focused proteomic approach." Ann N Y Acad Sci. 2008 Dec;1147:348-57.

Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL. (2008) "HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma." Cancer Cell. 2008 Dec 9;14(6):423-4.

Shikuma CM, Gerschenson M, Chow D, Libutti DE, Willis JH, Murray J, Capaldi RA, Marusich M. (2008) "Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy status." AIDS Res Hum Retroviruses. 2008 Oct;24(10):1255-62.

Murray J, Oquendo CE, Willis JH, Marusich MF, Capaldi RA. (2008) "Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress." Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1497-503.

Willis JH, Isaya G, Gakh O, Capaldi RA, Marusich MF. (2008) "Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers." Mol Genet Metab. 2008 Aug;94(4):491-7.

Murray J, Oquendo CE, Willis JH, Marusich MF, Capaldi RA. (2008) "Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress." Adv Drug Deliv Rev. 60(13-14):1497-503.

Will Y, Dykens JA, Nadanaciva S, Hirakawa B, Jamieson J, Marroquin LD, Hynes J, Patyna S, Jessen BA. (2008) "Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells." Toxicol Sci. 2008 Nov;106(1):153-61.

Dykens J, Jamieson J, Marroquin L, Nadanaciva S, Xu J, Dunn M, Smith A, Will Y. (2008) "In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone and Buspirone." Toxicol Sci. 2008 Jun;103(2):335-45.

  2007

Detmer SA, Chan DC. (2007) "Functions and dysfunctions of mitochondrial dynamics." Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9.

Nadanaciva S, Dykens J, Bernal A, Capaldi R. (2007) "Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration." Tox and Applied Pharma. 223(3): 277-87.

Hajek P, Chomyn A, Attardi G. (2007) "Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2." J. Biol. Chem. 282(8): 5670-81.

Murray J, Schilling B, Row RH, Yoo CB, Gibson BW, Marusich MF, Capaldi RA. (2007 in press) "Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount." Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78.

Nadanaciva S, Bernal A, Aggeler R, Capaldi R, Will Y. (2007) "Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays." Toxicol In Vitro. 21(5): 902-11.

Xie J, Marusich MF, Souda P, Whitelegge J, Capaldi RA. (2007) "The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11." FEBS Lett. 2007 Jul 24;581(18):3545-9.

Detmer SA, Chan DC. (2007) "Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations." J Cell Biol. 2007 Feb 12;176(4):405-14.

  2006

Guan MX, Yan Q, Li X, Bykhovskaya Y, Gallo-Teran J, Hajek P, Umeda N, Zhao H, Garrido G, Mengesha E, Suzuki T, del Castillo I, Peters JL, Li R, Qian Y, Wang X, Ballana E, Shohat M, Lu J, Estivill X, Watanabe K, Fischel-Ghodsian N. "Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations." Amer. J. Hum. Genet. 79(2): 291-302.

Hagiwara M, Yamagata K, Capaldi RA, Koyama A. (2006) "Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis." Kidney Int. 69(7): 1146-52.

Keeney PM, Xie J, Capaldi RA, Bennett JP Jr. (2006) "Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled." J. Neurosci. 26(19): 5256-64.

Schilling B, Murray J, Yoo CB, Row RH, Cusack MP, Capaldi RA, Gibson BW. (2006) "Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria." Biochim. Biophys. Acta. 1762(2): 213-22.

Walker DW, Hajek P, Muffat J, Knoepfle D, Cornelison S, Attardi G, Benzer S. (2006) "Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant." Proc. Natl. Acad. Sci. USA. 103(44): 16382-7.

Willis JH, Munro E, Lyczak R, Bowerman B. (2006) "Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform." Mol. Biol. Cell. 17(3): 1051-64.

Yonally SK, Capaldi RA. (2006) "The F(1)F(0) ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: An immunocytochemical study." Mitochondrion. 6: 305-14.

  2005

Burwick NR, Wahl ML, Moser TL, Li B, Capaldi RA, Kenan DJ, Pizzo SV. (2005) "An inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface." J. Biol. Chem. 280: 1740-5.

Encalada SE, Willis JH, Lyczak R, Bowerman B. (2005) "A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo." Mol. Biol. Cell. 16(3): 1056-70.

Schilling B, Aggeler R, Schulenberg B, Murray J, Row RH, Capaldi RA, Gibson BW. (2005) "Mass spectrometric identification of a novel phosphorylation site in subunit NDUFA10 of bovine mitochondrial complex I." FEBS Lett, 579: 2485-90.

Schilling B, Bharath S, Row RH, Murray J, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW. (2005) "Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and dopaminergic neuronal cell line." Mol. Cell Proteomics. 4: 84-96.

Slemmon JR, Painter CL, Nadanaciva S, Catana F, Kaup K, Scherrer R, Casadas V, Zhao Y, and Heron MI. (2005) "Analysis of protein fragmentation inhibition by an MMP-inhibitor in an in vivo model of heart failure using automated chromatography." J. Chromatogr. B. 819(2): 219-28.

  2004

Capaldi RA, Murray J, Byrne L, Janes MS, Marusich MF. (2004) "Immunological approaches to the characterization and diagnosis of mitochondrial disease." Mitochondrion. 4: 417-26.

Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. (2004) "Investigating mitochondrial redox potential with redox sensitive green fluorescent protein indicators." J. Biol. Chem. 279: 13044-53.

Janes MS, Hanson BM, Hill DM, Buller GM, Agnew J, Sherwood SW, Cox G, Yamagata K, Capaldi RA. (2004) "Rapid analysis of mitochondrial DNA depletion by fluorescence in situ hybridization and immunocytochemistry: potential strategies for HIV therapeutic monitoring." Hist. Cytochem. 52: 1011-8.

Koushika SP, Schaefer AR, Vincent R, Willis JH, Bowerman B, Nonet ML. (2004) "Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo." J. Neurosci. 24(16): 3907-16.

Murray J, Marusich MF, Capaldi RA, Aggeler R. (2004) "Focused proteomics: monoclonal antibody-based isolation of the oxidative phosphorylation machinery and detection of phosphoproteins by fluorescent phosphoprotein gel stain." Electrophoresis. 25: 2520-5.

Murray J, Yonally S, Aggeler R, Marusich MF, Capaldi RA. (2004) "Focused proteomics: towards a high throughput monoclonal antibody-based resolution of proteins for diagnosis of mitochondrial diseases." Biochim. Biophys. Acta. 1659: 206-11.

Oquendo CE, Antonicka H, Shoubridge EA, Reardon W, Brown GK. (2004) "Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome." J. Med. Genet. 41(7): 540-4.

Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA. (2004) "Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells." Cancer Res. 64: 985-93.

Schulenberg B, Goodman TN, Aggeler R, Capaldi RA, Patton WF. (2004) "Characterization of protein phosphorylation using a novel fluorescent phosphoprotein gel stain and mass spectrometry." Electrophoresis. 25: 2526-32.

Weber J, Wilke-Mounts S, Nadanaciva S, Senior AE. (2004) "Quantitative determination of direct binding of b subunit to F1 in Escherichia coli F1F0-ATP synthase." J. Biol. Chem. 279(12): 11253-8.


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